Description
Product Characteristics:
Voltage-gated sodium channels are selective ion channels that regulate the permeability of sodium ions in excitable cells. During the propagation of an action potential, sodium channels allow an influx of sodium ions, which rapidly depolarize the cell. The three glycoproteins that comprise the voltage-gated sodium channel proteins include a pore-forming Beta subunit, a noncovalently associated Beta 1 subunit and a disulfide-linked Beta 2 subunit. Na+ CP type VII Alpha (Sodium channel protein type 7 subunit alpha), also known as SCN6A, Sodium channel protein cardiac and skeletal muscle subunit alpha and putative voltage-gated sodium channel subunit alpha Nax, is a 1682 amino acid multi-pass membrane protein that belongs to the sodium channel family. Primarily expressed in uterus and heart, Na+ CP type VII Alpha may function in the regulation of salt intake behavior and central sensing of body-fluid sodium levels.
Subcellular location: Cell membrane
Synonyms: Putative voltage gated sodium channel subunit alpha Nax, SCN 6A, SCN 7A, SCN6A, Sodium channel protein cardiac and skeletal muscle subunit alpha, Sodium channel protein type 7 subunit alpha, Sodium channel protein type VII subunit alpha, Sodium channel voltage gated type VI alpha polypeptide, Sodium channel voltage gated type VII alpha, Sodium channel voltage gated type VII alpha polypeptide, Voltage dependent sodium channel alpha subunit, SCN7A_HUMAN.
Target Information: This gene encodes one of the many voltage-gated sodium channel proteins. For proper functioning of neurons and muscles during action potentials, voltage-gated sodium channels direct sodium ion diffusion for membrane depolarization. This sodium channel protein has some atypical characteristics\, the similarity between the human and mouse proteins is lower compared to other orthologous sodium channel pairs. Also, the S4 segments, which sense voltage changes, have fewer positive charged residues that in other sodium channels\, domain 4 has fewer arginine and lysine residues compared to other sodium channel proteins. Several alternatively spliced transcript variants exist, but the full-length natures of all of them remain unknown. [provided by RefSeq, Dec 2011]